过滤(数学)
流量(数学)
滤波器(信号处理)
停留时间(流体动力学)
停留时间分布
计算流体力学
材料科学
机械
体积流量
计算机科学
数学
地质学
物理
岩土工程
计算机视觉
统计
作者
Min-Young Kim,Negin Nejatishahidein,Ehsan Espah Borujeni,David J. Roush,Andrew L. Zydney,Ali Borhan
标识
DOI:10.1016/j.memsci.2020.118625
摘要
Depth filtration is widely used for clarification of liquid feeds, including the purification of biopharmaceuticals. The performance characteristics of these depth filters can be strongly influenced by the local flow and pressure distribution within the filter capsule, but there is currently little information on these phenomena in commercial depth filter modules. This work used a combination of computational fluid dynamics (CFD), residence time distribution (RTD) measurements, and dye binding experiments to obtain detailed information on the pressure and flow distribution within a small-scale Supracap™ depth filtration capsule, containing two layers of depth filter media with different pore size, that is of high interest in bioprocessing. The results confirmed the presence of four distinct flow paths through the capsule, with less than 40% of the flow passing completely through both layers of the depth filter media and nearly 11% bypassing the large pore size prefilter layer. Model calculations were in good agreement with the measured RTD and images of dye binding, providing further confirmation of the flow phenomena. These studies provide important insights into the performance characteristics of these depth filters, while providing a framework that can be applied to analyze the pressure and flow distribution in other membrane and depth filtration modules.
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