壳聚糖
化学
聚合物
共价键
肿胀 的
组合化学
广谱
纳米技术
胶粘剂
有机化学
高分子化学
材料科学
复合材料
图层(电子)
作者
Christoph Federer,Markus Kurpiers,Andreas Bernkop‐Schnürch
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2020-06-22
卷期号:22 (1): 24-56
被引量:76
标识
DOI:10.1021/acs.biomac.0c00663
摘要
Various properties of chitosan can be customized by thiolation for very specific needs in a wide range of application areas. Since the discovery of thiolated chitosans, many studies have proven their advantageous characteristics, such as adhesion to biological surfaces, adjustable cross-linking and swelling behavior, controllable drug release, permeation as well as cellular uptake enhancement, inhibition of efflux pumps and enzymes, complexation of metal ions, antioxidative properties, and radical scavenging activity. Simultaneously, these polymers remain biodegradable without increased toxicity. Within this Review, an overview about the different possibilities to covalently attach sulfhydryl ligands to the polymeric backbone of chitosan is given, and the resulting versatile physiochemical properties are discussed in detail. Furthermore, the broad spectrum of applications for thiolated chitosans in science and industry, ranging from their most advanced use in pharmaceutical and medical science over wastewater treatment to the impregnation of textiles, is addressed.
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