子宫内膜炎
生育率
子宫内膜
子宫
生物
精液
不育
免疫系统
炎症
概念
医学
免疫学
生理学
男科
怀孕
内分泌学
人口
遗传学
妊娠期
环境卫生
作者
Lee Morris,Patrick M. McCue,Christine Aurich
出处
期刊:Reproduction
[Bioscientifica]
日期:2020-09-08
卷期号:160 (5): R95-R110
被引量:97
摘要
Endometritis in the mare begins as a normal physiological inflammatory response to breeding that involves both a mechanical and immunological response pathway activated to rid the uterus of semen and bacteria. With successful resolution of this inflammation, the mare's uterus will provide a hospitable environment for the development of the semi-allogenic conceptus. If the mare fails to resolve this inflammatory response within 48 h of breeding, she will become susceptible to persistent breeding-induced endometritis (PBIE) which will have detrimental effects on her fertility. This condition can then predispose the mare to bacterial or fungal endometritis leading to further degeneration of the endometrium. Optimisation of the mare's fertility requires a fine balance between allowing the natural immune response of the endometrium to its exposure to allogenic semen to run its course, and yet preventing its progression to PBIE or the involvement of infectious agents. This review discusses the challenges presented by PBIE, latent infections, biofilms, fungal infections and the need to utilise diagnostic methods available and implement targeted treatments to optimise fertility in the mare.
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