黄芩素
黄芩
黄芩苷
NF-κB
炎症
免疫印迹
药理学
αBκ
免疫学
发病机制
医学
沃戈宁
信号转导
化学
中医药
病理
生物化学
替代医学
高效液相色谱法
色谱法
基因
作者
Tingting Xu,Xiangting Ge,Chun Lu,Wei Dai,Hongjin Chen,Zhifeng Xiao,Liqin Wu,Guang Liang,Songmin Ying,Yali Zhang,Yuanrong Dai
出处
期刊:Aging
[Impact Journals, LLC]
日期:2019-11-06
卷期号:11 (21): 9310-9327
被引量:28
标识
DOI:10.18632/aging.102371
摘要
Asthma is a type of chronic lung inflammation with restrictions in effective therapy. NF-κB pathway activation has been suggested to play an important role in the pathogenesis of asthma. Baicalein, one of the major active flavonoids found in Scutellaria baicalensis, exhibits potent anti-inflammatory properties by inhibiting NF-κB activity. Herein, we report that Baicalein significantly reduces OVA-induced airway hyperresponsiveness (AHR), airway inflammation, serum IgE levels, mucus production, and collagen deposition around the airway. Additionally, western blot analysis and immunofluorescence assay showed that Baicalein attenuates the activation of NF-κB, which was mainly reflected by IκBα phosphorylation and degradation, p65 nuclear translocation and downstream iNOS expression. Furthermore, in human epithelial cells, Baicalein blocked TNF-α-induced NF-κB activation. Our study provides evidence that Baicalein administration alleviates the pathological changes in asthma through inactivating the NF-κB/iNOS pathway. Baicalein might be a promising potential therapy agent for patients with allergic asthma in the future.
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