免疫检查点
癌症研究
癌症
癌症免疫疗法
肿瘤微环境
免疫疗法
提吉特
彭布罗利珠单抗
出处
期刊:Cancer immunology research
[American Association for Cancer Research]
日期:2021-02-01
卷期号:9 (2): 128-128
被引量:2
标识
DOI:10.1158/2326-6066.cir-20-0996
摘要
Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2+ tumor cells from immune attack.See article by Bhatt et al., p. 156.
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