壳聚糖
甲壳素
自愈水凝胶
胶粘剂
右旋糖酐
化学
体内
肿胀 的
细胞毒性
止血
席夫碱
粘附
高分子化学
材料科学
生物化学
体外
有机化学
复合材料
外科
生物
生物技术
图层(电子)
医学
作者
Jianhui Pang,Shichao Bi,Tiantian Kong,Xin Luo,Zhongzheng Zhou,Kaijin Qiu,Liang Huang,Xiguang Chen,Ming Kong
标识
DOI:10.1016/j.carbpol.2020.116138
摘要
Schiff base reaction crosslinking hydrogels are advantageous by rapid formation and absence of external crosslinkers. However, poor mechanical hindered their broader applications. Here, a mechanically strengthened tissue adhesive was constructed through incorporation of chitin nano-whiskers (CtNWs) with a Schiff base crosslinking hydrogel of carboxymethyl chitosan (CMCS) and dextran dialdehyde (DDA). The optimal formulation of complexed hydrogel exhibited 1.87 folds higher compressive stress than non-complexed and 1.51 time higher adhesive strength on porcine skin. The complexed hydrogel exhibited negligible cytotoxicity, anti-swelling performance in PBS, optimum antibacterial and hemostatic capacities. In vivo implantation studies confirmed the complexed hydrogel was degradable without long-term inflammatory responses. Desirable efficacy of injectable complexed hydrogel as hemostat was demonstrated in rat liver injury model, which could avoid severe postoperative adhesion and necrosis as observed in the treatment with commercial 3 M™ vetbond™ tissue adhesive. The results highlighted that the complexed hydrogel potentiated rapid hemostasis and wound repair applications.
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