单线态氧
材料科学
光热治疗
癌症研究
荧光
光化学
纳米颗粒
纳米团簇
荧光寿命成像显微镜
作者
Han Ren,Miao Zhao,Zhiwei Wang,Helin Liu,Shengcang Zhu,Lu Huang,Yu Wang,Lijun Wang,Yu Hong,Sha Yan,Yuqiang Jiang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2019-10-31
卷期号:14 (8): 9532-9544
被引量:98
标识
DOI:10.1021/acsnano.9b05169
摘要
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic technique that can induce the regression of targeted lesions via generating excess cytotoxic reactive oxygen species. However, due to the limited penetration depth of visible excitation light and the intrinsic hypoxia microenvironment of solid tumors, the efficacy of PDT in the treatment of cancer, especially deep-seated or large tumors, is unsatisfactory. Herein, we developed an efficient in vivo PDT system based on a nanomaterial, dihydrolipoic acid coated gold nanocluster (AuNC@DHLA), that combined the advantages of large penetration depth in tissue, extremely high two-photon (TP) absorption cross section (σ2 ∼ 106 GM), efficient ROS generation, a type I photochemical mechanism, and negligible in vivo toxicity. With AuNC@DHLA as the photosensitizer, highly efficient in vivo TP-PDT has been achieved.
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