黄芩素
黄芩苷
沃戈宁
黄芩
四氯化碳
药理学
黄芩
肝毒素
天冬氨酸转氨酶
传统医学
肝损伤
体内
医学
四氯化碳
化学
毒性
生物化学
碱性磷酸酶
中医药
内科学
生物
病理
酶
色谱法
高效液相色谱法
替代医学
生物技术
有机化学
作者
Chun‐Ching Lin,Den‐En Shieh
标识
DOI:10.1002/(sici)1099-1573(199612)10:8<651::aid-ptr651>3.3.co;2-c
摘要
The in vivo hepatoprotective effect of baicalein, baicalin and wogonin, three major components isolated from Scutellaria rivularis Benth. were investigated in three experimental models. Liver damage was induced by acetaminophen (APAP), carbon tetrachloride (CCl4) and β-D-galactosamine (D-GalN) in rats. Significant protective effects were seen by comparing the serum glutamate oxaloacetate transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT) and histopathologic examination. All tested drugs, especially wogonin (5 mg/kg), markedly decreased the toxicity produced by D-GalN (p<0.01). Wogonin (5, 10 mg/kg) also decreased APAP-induced hepatotoxicity. Baicalin (10 mg/kg) exhibited the best hepatoprotective effect on CCl4-induced liver injuries, but had no significant effect on APAP-induced intoxication. In histopathologic observation, hepatic lesions caused by three hepatotoxins were markedly improved in drug-treated groups, compared with glycyrrhizin (GLZ) as a standard reference medicine.
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