真菌多样性
底漆(化妆品)
多样性(政治)
次生代谢
竞赛(生物学)
计算生物学
次生代谢物
生物
遗传学
微生物学
生物技术
进化生物学
植物
生态学
生物合成
社会学
基因
人类学
作者
Sonja L. Knowles,Huzefa A. Raja,Christopher D. Roberts,Nicholas H. Oberlies
摘要
Covering: 2002 to 2020In their natural environment, fungi must compete for resources. It has been hypothesized that this competition likely induces the biosynthesis of secondary metabolites for defence. In a quest to discover new chemical diversity from fungal cultures, a growing trend has been to recapitulate this competitive environment in the laboratory, essentially growing fungi in co-culture. This review covers fungal-fungal co-culture studies beginning with the first literature report in 2002. Since then, there has been a growing number of new secondary metabolites reported as a result of fungal co-culture studies. Specifically, this review discusses and provides insights into (1) rationale for pairing fungal strains, (2) ways to grow fungi for co-culture, (3) different approaches to screening fungal co-cultures for chemical diversity, (4) determining the secondary metabolite-producing strain, and (5) final thoughts regarding the fungal-fungal co-culture approach. Our goal is to provide a set of practical strategies for fungal co-culture studies to generate unique chemical diversity that the natural products research community can utilize.
科研通智能强力驱动
Strongly Powered by AbleSci AI