自愈水凝胶
再生(生物学)
生物医学工程
心肌梗塞
组织工程
材料科学
心力衰竭
纳米复合材料
纳米技术
心脏病学
医学
内科学
高分子化学
生物
细胞生物学
作者
Behnam Pournemati,Hadi Tabesh,Alireza Jenabi,Rouhollah Mehdinavaz Aghdam,Ali Hossein Rezayan,Ali Poorkhalil,Seyed Hossein Ahmadi Tafti,K. Mottaghy
标识
DOI:10.1016/j.eurpolymj.2022.111336
摘要
Cardiovascular diseases are the leading cause of death today and a significant public health problem. Currently, there is no proper treatment for major cardiovascular diseases such as myocardial infarction (MI) as the heart has a very limited innate capacity for regeneration. Although available therapeutical procedures, e.g. pharmacological interventions, coronary artery bypass graft surgery, and ventricular assistant devices, have significantly improved patients’ quality of lives and prolonged their longevities, these ameliorating therapies do not regenerate the injured cardiac tissue. Over the last decade, many studies have been devoted to develop various types of scaffolds for regeneration cardiac tissue especially post-myocardial infarction heart failure. Utilizing injectable conductive hydrogels as a minimally invasive method showed acceptable physicochemical and mechanical properties in vivo; and thus, it turns to a promising approach in field of cardiac tissue engineering (CTE). This review focuses on exploring different electroconductive nanoparticles (i.e. metal- and carbon-based) integrated with natural and synthetic injectable hydrogels. Moreover, the physical effect of these nanostructures in terms of conductivity enhancement and mechanical moduli improvement on hydrogels has been compared and evaluated. Eventually, optimized future injectable conductive hydrogel intended to be used for CTE is discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI