Catalytic asymmetric construction of dispirotriheterocyclic structures through [3+2] cycloadditions of 4-amino pyrazolone-based azomethine ylides

An efficient and convenient catalytic asymmetric [3+2] cycloaddition of 4-amino pyrazolone-based azomethine ylides was developed, which delivers the multi-pharmacophore-containing dispirotriheterocyclic scaffolds with excellent stereoselectivities.