细胞毒性T细胞
NKG2D公司
颗粒酶B
免疫系统
白细胞介素21
颗粒酶
生物
糖尿病
自然杀伤细胞
淋巴因子激活杀伤细胞
免疫学
白细胞介素12
穿孔素
细胞毒性
CD8型
内分泌学
内科学
癌症研究
医学
体外
生物化学
作者
Dae Yoon Kim,Jae Kwon Lee
标识
DOI:10.1016/j.cellimm.2022.104578
摘要
Diabetes mellitus (DM), also called diabetes, is a chronic metabolic disorder, with complications that include failure of immune responses, such as immune cell proliferation and activation. The current study investigated changes in natural killer (NK) cell activity under diabetic conditions. To demonstrate the influence of hyperglycemia on NK cell activity, type 1 and 2 diabetes models were constructed using C57/BL6 mice. NK cells isolated from mice with either type 1 or 2 diabetes showed lower cytotoxic activity against cancer cells than NK cells isolated from healthy control mice, and the longer the duration since induction of diabetes, the lower was the cytotoxic activity. Moreover, in the diabetic mouse models, fewer NK cells expressed activation markers, such as NKG2D and NKp46, compared to NK cells from control mice. Production of the apoptosis inducer, granzyme B, was also lower in NK cells from diabetic mice than control mice. These results demonstrate that high glucose conditions influence NK cell activity.
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