启动(农业)
生物
细胞毒性T细胞
效应器
CD8型
细胞生物学
T细胞
免疫学
免疫系统
CD28
遗传学
植物
发芽
体外
作者
Changwei Peng,Matthew A Huggins,Kelsey M. Wanhainen,Todd P. Knutson,Hanbin Lu,Hristo Georgiev,Kristen Mittelsteadt,Nicholas N. Jarjour,Haiguang Wang,Kristin A. Hogquist,Daniel Campbell,Henrique Borges da Silva,Stephen C. Jameson
出处
期刊:Immunity
[Elsevier]
日期:2022-01-01
卷期号:55 (1): 98-114.e5
被引量:32
标识
DOI:10.1016/j.immuni.2021.11.017
摘要
Elevated gene expression of the costimulatory receptor Icos is a hallmark of CD8+ tissue-resident memory (Trm) T cells. Here, we examined the contribution of ICOS in Trm cell differentiation. Upon transfer into WT mice, Icos-/- CD8+ T cells exhibited defective Trm generation but produced recirculating memory populations normally. ICOS deficiency or ICOS-L blockade compromised establishment of CD8+ Trm cells but not their maintenance. ICOS ligation during CD8+ T cell priming did not determine Trm induction; rather, effector CD8+ T cells showed reduced Trm differentiation after seeding into Icosl-/- mice. IcosYF/YF CD8+ T cells were compromised in Trm generation, indicating a critical role for PI3K signaling. Modest transcriptional changes in the few Icos-/- Trm cells suggest that ICOS-PI3K signaling primarily enhances the efficiency of CD8+ T cell tissue residency. Thus, local ICOS signaling promotes production of Trm cells, providing insight into the contribution of costimulatory signals in the generation of tissue-resident populations.
科研通智能强力驱动
Strongly Powered by AbleSci AI