化学
效力
溶解度
共价键
代谢稳定性
体内
酮
组合化学
铅化合物
小分子
电泳剂
加合物
生物化学
体外
有机化学
催化作用
生物技术
生物
作者
Marie Helene Larraufie,Wan Seok Yang,Elise Jiang,Ajit G. Thomas,Barbara S. Slusher,Brent R. Stockwell
标识
DOI:10.1016/j.bmcl.2015.07.018
摘要
Introducing a reactive carbonyl to a scaffold that does not otherwise have an electrophilic functionality to create a reversible covalent inhibitor is a potentially useful strategy for enhancing compound potency. However, aldehydes are metabolically unstable, which precludes the use of this strategy for compounds to be tested in animal models or in human clinical studies. To overcome this limitation, we designed ketone-based functionalities capable of forming reversible covalent adducts, while displaying high metabolic stability, and imparting improved water solubility to their pendant scaffold. We tested this strategy on the ferroptosis inducer and experimental therapeutic erastin, and observed substantial increases in compound potency. In particular, a new carbonyl erastin analog, termed IKE, displayed improved potency, solubility and metabolic stability, thus representing an ideal candidate for future in vivo cancer therapeutic applications.
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