Objective: To observe the effects of oral stimulation and non- nutritive sucking on sucking ability in premature infants with feeding difficulties per os. Methods: 62 cases of premature infants were randomly divided into experimental group and control group with 31 cases in each group. The two groups were given prevent infection,parenteral nutrition,small dose of golden bifid,nasal feeding based support treatment,the experimental group added the oral cavity massage and non- nutritive sucking. The clinical effects of two groups were compared. Results: The two groups after the treatment of feeding intolerance in preterm infants in the mean time,indwelling gastric tube,oral feeding time,after 3 weeks' weight and other aspects of comparison,with statistical significance( P 0. 05). Conclusion: Oral stimulation and non- nutritive sucking combined with foundation support treatment for premature infants improves their nutritional status,and yields better feeding outcomes and tolerability.