Effect of lidocaine on myocardial Na+-K+-ATPase,Ca~(2+)-Mg~(2+)-ATPase and serum NO during myocardial ischemia/reperfusion injury in rabbits

Objective:To study the effect of lidocaine on myocardial Na+-K+-ATPase,Ca2+-Mg2+-ATPase and serum NO during myocardial ischemia/reperfusion injury in rabbits.Methods:24 rabbits were randomly divided into three groups,that is,sham operation group(group A),ischemia/reperfusion injury group(group B),lidocaine group(group C),with 8 rabbits in each group.The left coronary artery anterior desending branch was blocked in groups B and C for 40 minutes,and then the reperfusion was performed for 90 minutes,while group A only braided and not being ligated.The jugular vein in group C was injected with lidocaine 5 mg/kg before reperfusion,while the groups B and A were injected with equivalent physiological saline.After reperfusion,the jugular blood was drawn to determine NO,while the myocardial tissue was taken to determine NOS,Na+-K+-ATPase and Ca2+-Mg2+-ATPase.Results:The myocardial tissue Ca2+-Mg2+-ATPase in group B was lower than that in groups A and C(P0.01);the serum NO and myocardial tissue Na+-K+-ATPase and NOS in group B were lower than those in groups A and C(all P0.01).Conclusion:Lidocaine plays a protective role on cardiac muscle during myocardial ischemia/reperfusion injury.