The Synthesis of Medicinal Intermediates 1,4-N,N-substituted Piperazines

bis-(2-chloroethy1)amine was synthesized from raul material diethanolamine with SOCl2 in this study.1-(3-chloropheny1)piperazine was obtained in the substituted reaction of bis-(2-chloroethy1)amine with 3-chloroaniline,and reacted with 1-bromo-3-chloropropane to give 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine.The 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine is important medicinal intermediates to preparation of 1,4-N,N-substituted piperazines.