Effect of hydrochloride fasudil on IL-1β,TNF-α and RHO kinose in serum of patients with cerebral infarction

Objective: To explore effect of hydrochloride fasudil on IL-1β,TNF-α and RHO kinose in serum of patients with cerebral infarction.Methods: A total of 186 cases with cerebral infarction were divided into two groups.Patients in observation group were treated by routine therapy and hydrochloride fasudil;while patients in control group were treated by routine therapy.Expressions of IL-1β,TNF-α and RHO kinase were detected before and after treatment.The efficacy and changes of IL-1β,TNF-α and RHO kinase in serum were observed and compared.Results: The efficacy was higher in the observation group than in the control group.The expressions of IL-1β,TNF-α and RHO kinase were significantly decreased after treatment.But the decrease of IL-1β,TNF-α and RHO kinase were more significant in the observation group than in the control group.Conclusions: Hydrochloride fasudil can improve the efficacy,inhibit the expressions of IL-1β,TNF-α and RHO kinase,and protect the cerebral cells in patients with cerebral infarction.