Analgesia and pharmacodynamics of Wutou injection in mice

OBJECTIVE To study the analgesia effects and pharmacodynamics of Wutou injection.METHODS The mice were treated ip once with Wutou injection (2 mg·kg -1 ) and morphine (10 mg·kg -1 ) was used as the positive control.The changes of reactive latent period on hot-plate were observed.The apparent parameters of pharmacodynamics were estimated based on the time-effect curve.RESULTS The Wutou injection had analgesic effect obviously.Its effect-time curve ws conformed to one-compartment modle of extravascular administration.The apparent parameters of the pharmacodynamics were: K a=0.026539 min -1 ; t 1/2a =26.12 min; k e=0.007968 min -1 ; t 1/2E =87 min; t max =80.16 min; E max =149.24 ΔE%(58.27 s),respectively.CONCLUSION The Wutou injection had analgesic effect obviouly.The parameters of pharmacodynamics may be helpful for physicians clinic.