Effects of dexmedetomidine and midazolam on cardiovascular response of general anesthesia patients undergoing laproscopic cholecystectomy during decannulation period

Objective To investigate the effects of dexmedetomidine and midazolam on cardiovascular response of general anesthesia patients undergoing laproscopic cholecystectomy(LC) during decannulation period.Methods One hundred patients with hypertension underwent LC were randomly divided into two groups.The scheme of induction and maintenance of anesthesia of the two groups were identical.However,patients in dexmedetomidine group were administered with dexmedetomidine 1 μg/kg over 10 mins and midazolam 0.05 mg/kg over 10 mins in midazolam group.Before induction,at the time of extubation and 1 min post extubation,systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),the recovery time,extubation time and adverse effects were recorded,RPP were also calculated.Results SBP,DBP,HR,RPP in dexmedetomidine group at the time of extubation and 1 min post extubation were significantly lower than those in midazolam group.And even 5 min post extubation,RPP value in dexmedetomidine group was still significantly lower than that in midazolam group(all P0.05).In addition,the above parameters were statistically elevated in midazolam group at extubation and 1 min post extubation compared to parameters before induction(all P0.05).Conclusions Dexmedetomidine can effectively attenuate the cardiovascular response to extubation in patients with hypertension undergoing laproscopic cholecystectomy and also can strengthen the safety degree of tracheal extubation.