Embedding Raman Tags between Au Nanostar@Nanoshell for Multiplex Immunosensing

Novel Raman tags with various reporter molecules embedded in between gold nanostar (AuNS) and gold nanoshell are developed, showing significantly enhanced surface-enhanced Raman scattering intensity compared to gold nanoparticle-based composites. Immunoassay using these AuNS@tag@shell structures is highly specific with sensitivity down to 0.1 pg mL-1 , and is capable of multiplex detection, making them highly promising for biosensing applications.