G蛋白偶联受体
生物
受体
视紫红质样受体
溶血磷脂酸
肿瘤微环境
细胞生物学
癌症
信号转导
癌症研究
生物化学
兴奋剂
代谢受体
遗传学
作者
Ying Liu,Su An,Richard J. Ward,Yang Yang,Xuewu Guo,Wei Li,Tian‐Rui Xu
出处
期刊:Cancer Letters
[Elsevier]
日期:2016-07-01
卷期号:376 (2): 226-239
被引量:92
标识
DOI:10.1016/j.canlet.2016.03.031
摘要
G protein-coupled receptors (GPCRs) regulate an array of fundamental biological processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved in cancer initiation and progression. However, compared with the involvement of the epidermal growth factor receptor in cancer, that of GPCRs have been largely ignored. Recent findings have implicated many GPCRs in tumorigenesis, tumor progression, invasion and metastasis. Moreover, GPCRs contribute to the establishment and maintenance of a microenvironment which is permissive for tumor formation and growth, including effects upon surrounding blood vessels, signaling molecules and the extracellular matrix. Thus, GPCRs are considered to be among the most useful drug targets against many solid cancers. Development of selective ligands targeting GPCRs may provide novel and effective treatment strategies against cancer and some anticancer compounds are now in clinical trials. Here, we focus on tumor related GPCRs, such as G protein-coupled receptor 30, the lysophosphatidic acid receptor, angiotensin receptors 1 and 2, the sphingosine 1-phosphate receptors and gastrin releasing peptide receptor. We also summarize their tissue distributions, activation and roles in tumorigenesis and discuss the potential use of GPCR agonists and antagonists in cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI