吲哚青绿
体内
光热治疗
癌细胞
药物输送
纳米医学
癌症
生物医学工程
材料科学
癌症研究
纳米技术
化学
生物物理学
医学
病理
纳米颗粒
生物
生物技术
内科学
作者
Peng Huang,Yuan Gao,Jing Lin,Hao Hu,Hsien-Shun Liao,Xuefeng Yan,Yuxia Tang,Albert J. Jin,Jibin Song,Gang Niu,Guofeng Zhang,Ferenc Horkay,Xiaoyuan Chen
出处
期刊:ACS Nano
[American Chemical Society]
日期:2015-08-27
卷期号:9 (10): 9517-9527
被引量:181
标识
DOI:10.1021/acsnano.5b03874
摘要
Despite the effort of developing various nanodelivery systems, most of them suffer from undesired high uptakes by the reticuloendothelial system, such as liver and spleen. Herein we develop an endogenous phosphatase-triggered coassembly strategy to form tumor-specific indocyanine green (ICG)-doped nanofibers (5) for cancer theranostics. Based on coordinated intermolecular interactions, 5 significantly altered near-infrared absorbance of ICG, which improves the critical photoacoustic and photothermal properties. The phosphatase-instructed coassembly process, as well as its theranostic capability, was successfully conducted at different levels ranging from in vitro, living cell, tissue mimic, to in vivo. Specifically, the tumor uptake of ICG was markedly increased to 15.05 ± 3.78%ID/g, which was 25-fold higher than that of free ICG (0.59 ± 0.24%ID/g) at 4 h after intravenous injection. The resulting ultrahigh T/N ratios (>15) clearly differentiated tumors from the surrounding normal tissue. Complete tumor elimination with high therapeutic accuracy has been successfully achieved upon laser irradiation (0.8 W/cm(2), 5 min) within 24-48 h postinjection. As the first example, in vivo formation of tumor-specific ICG-doped nanofiber for PTT theranostics owns the immense potential for clinical translation of personalized nanomedicine with targeted drug delivery as well as for cancer theranostics.
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