Metabolism and Elimination of Oxytetracycline in Hepatopancreas of Chinese Mitten Crab Eriocheir Sinensis

The kinetic profiles of Oxytetracycline (OTC) in hepatopancreas of Eriocheir sinensis was examined in this research. The results showed that after a single-dose of 40 mg/kg body weight OTC at (18±1°C) by intramuscular administration, the hepatopancreas concentration-time curve of OTC could be best described by a one-compartment model with first-order absorption and a time lag: C = 69.45×(e-0.005(t-0.0387)-e-8.195 (t- 0.0387)). The elimination half-life (t1/2β) was 130.71 h. It is suggested that a withdrawal time of 79.51d should be required before crabs are consumed safely.