An oral–gut microbial metabolite links Fusobacterium nucleatum to aggravated myocardial ischemia–reperfusion injury

F. nucleatum reshapes gut microbial metabolism, thereby amplifying MIRI via ImP. ImP emerges as a functional mediator linking oral dysbiosis to MIRI, and reducing microbiota-derived ImP may represent a more mechanistically grounded strategy to mitigate MIRI.