Photoredox/Cobalt Dual Catalysis Enables C(sp3)C(sp2)/C(sp) Bond Construction via a Biomimetic Approach

We developed a photoredox–cobalt synergistic biomimetic reaction, constructing an unsaturated molecular library. Remarkably, we demonstrate the synthesis of a series of polysubstituted cinnamaldehydes. Furthermore, reported an unprecedented property of α‑fluoroalkyl compounds, defluorination was absent in the presence of a cobaloxime catalyst or vitamin B12, but pronounced without cobalt catalyst. This revealed the catalytic commonality