极限抗拉强度
聚氨酯
膜
成纤维细胞
硅氧烷
材料科学
体内
伤口愈合
粘附
明胶
吸水率
移植
伤口敷料
生物医学工程
高分子化学
化学
复合材料
体外
外科
聚合物
医学
有机化学
生物化学
生物技术
生物
作者
Alireza Rezapour,Hamid Yeganeh,Seyed Nasser Ostad,Reza Gharibi,Zohreh Mazaheri,Jafar Ai
标识
DOI:10.1016/j.msec.2016.07.067
摘要
Polyurethane/siloxane based wound dressing for transferring fibroblast cell sheet to wounded skin and ability to provide an optimum condition for cellular activity at damaged tissue was prepared in this research. The dressing was made thermoresponsive, via the introduction of a poly(N-isopropyl acrylamide) copolymer into the backbone of dressing. The ability of membrane for adhesion, growth, and proliferation of fibroblast cells was improved via surface modification with gelatin. The optimized dressing exhibited appropriate tensile strength (4.5 MPa) and elongation at break (80%) to protect wound against physical forces. Due to controlled equilibrium water absorption of about 89% and water vapor transmission rate of 2040 g/m2 day, the dressing could maintain the favorable moist environment over moderate to high exuding wounds. The grown cell sheet on dressing membrane could easily roll up from the surface just with lowering the temperature. The in vivo study of the wound dressed with cell loaded membrane confirmed the accelerated healing and production of tissue with complete re-epithelization, enhanced vascularization, and increased collagen deposition on the damaged area.
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