生物传感器
生物过程
纳米技术
生化工程
核糖开关
分析物
合成生物学
微流控
计算机科学
计算生物学
化学
生物
工程类
材料科学
生物化学
物理化学
基因
基因表达
古生物学
非编码RNA
作者
Linda Dekker,Karen M. Polizzi
标识
DOI:10.1016/j.cbpa.2017.05.014
摘要
Biosensors use biological elements to detect or quantify an analyte of interest. In bioprocessing, biosensors are employed to monitor key metabolites. There are two main types: fully biological systems or biological recognition coupled with physical/chemical detection. New developments in chemical biosensors include multiplexed detection using microfluidics. Synthetic biology can be used to engineer new biological biosensors with improved characteristics. Although there have been few biosensors developed for bioprocessing thus far, emerging trends can be applied in the future. A range of new platform technologies will enable rapid engineering of new biosensors based on transcriptional activation, riboswitches, and Förster Resonance Energy Transfer. However, translation to industry remains a challenge and more research into the robustness biosensors at scale is needed.
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