SP200CHRONIC KIDNEY DISEASE AND MORTALITY IN LONG-TERM SURVIVORS OF AN EPISODE OF ACUTE RENAL INJURY

Introduction and Aims: Several population studies have shown an association between acute kidney injury (AKI ) and subsequent development of chronic kidney disease (CKD ). However, the assessment of the risk profile for this complication are scarce, and little is known on the impact of cardiovascular risk factors. The aim of this study is to evaluate the impact of AKI episode in the subsequent development of CKD, mortality and morbidity in the midterm follow-up (12 months) and long term follow-up(24 months). Methods: Retrospective study of patients diagnosed with AKI (ICD- 9) as ADQI criteria definition, with full renal recovery at discharge. We included demographic, clinical and laboratory data at 12 months and 4 years follow-up. Results: 498 patients were included, 61.8 % men, mean age 66.2 ± 19 years. At discharge, 386 patients (78.6 %) recovered renal function. Follow-up at 12 months showed that 122 (22.1 %) patients developed CKD and after 4 years follow-up, CKD was diagnosed in 106 patients (40.8%). Multivariate analysis showed that history of hypertension (OR: 1.62, 95% CI 1.2-2.6, p < 0.05) and serum creatinine > 2.6 mg / dl during the AKI episode (OR: 1.7, 95% CI 1.2-3.7, p < 0.05) are risk factors for CKD at 12 months, while at 4 years, the risk of CKD is associated with age (p < 0.05), hypertension (p < 0.05) and peripheral vascular disease (p < 0.05).