化学
二茂铁
细胞凋亡
生物活性
呋喃
质谱法
碳-13核磁共振
路易斯酸
毒性
核化学
组合化学
立体化学
有机化学
体外
色谱法
生物化学
催化作用
物理化学
电化学
电极
作者
Mustafa Tombul,Adnan Bulut,Mustafa Türk,Büşra Uçar,Özer Işılar
标识
DOI:10.1080/15533174.2016.1218510
摘要
Due to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1–5 were obtained in moderate yields and characterized by IR, 1H-NMR, 13C-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 µg/mL concentration, the protection of cell viability was observed to be 70% level. At 50 µg/mL concentration, apoptosis in cancer cells observed was 63 ± 4% leading to high apoptosis ratio for the compound 3. For the compounds (1–5), the necrotic effects were found to be between 21% and 39% at 50 µg/mL concentration.
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