Cohort Profile: The AMORIS cohort

Why was the cohort set up?During the period 1985-96, the Central Automation Laboratory (CALAB), Stockholm, Sweden was a leading centre for analyses of blood and urine samples from health screenings and primary health care in Sweden.The results from these analyses were secured as a resource for future research.The AMORIS (Apolipoprotein-related MOrtality RISk) cohort was initiated by Ingmar Jungner (I.J.), one of the founders of CALAB, and Go ¨ran Walldius (G.W.), the scientific research coordinator.This AMORIS cohort was originally set up to test if levels of apolipoprotein (apo) B (atherogenic) and apoA-I (atheroprotective) were more closely related to fatal myocardial infarction and stroke than conventional lipids, especially low-density lipoprotein (LDL)-cholesterol.In 2012 I.J. donated the CALAB database to the Karolinska Institutet, Stockholm, Sweden, for research purposes to support the research project 'Epidemiologic studies of metabolic factors and inflammation in relation to chronic disease'.The CALAB database was further updated in 2012-14 by means of record linkages to 24 different Swedish national health registers, registers of quality of care, and surveys including socioeconomic data as well as a questionnaire and biomedical data from number of research cohorts (Figure 1).This research project complies with the Declaration of Helsinki and was