重编程
再生医学
诱导多能干细胞
组织工程
干细胞
细胞分化
生物材料
生物
细胞生物学
体细胞
胚胎干细胞
细胞
生物医学工程
医学
遗传学
基因
作者
Bharath Kumar Velmurugan,Lohanathan Bharathi Priya,Paramasivan Poornima,Li-Jen Lee,Rathinasamy Baskaran
摘要
Abstract Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self‐renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.
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