细胞凋亡
程序性细胞死亡
细胞
癌症
生物
疾病
癌症研究
化学
细胞生物学
生物化学
医学
内科学
遗传学
作者
Pelin Çıkla-Süzgün,Ş. Güniz Küçükgüzel
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2019-09-25
卷期号:19 (17): 1427-1442
被引量:16
标识
DOI:10.2174/1389557519666190410125910
摘要
The process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Promotion of apoptosis may be a good approach for the prevention of cancer cell proliferation. In early studies, antitumor compounds have been found to induce the apoptotic process in tumor cells. On the other hand, several hydrazones were reported to have lower toxicity than hydrazides due to the blockage of -NH2 group. Therefore, the design of hydrazones that activate and promote apoptosis is an attractive strategy for the discovery and development of potential anticancer agents. The aim of this review is to provide a general overview of current knowledge and the connection between apoptosis and hydrazone. It is also the guide for the apoptotic activities of new hydrazone derivatives.
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