生物
寨卡病毒
病毒学
病毒复制
核糖核酸酶P
发病机制
病毒
机制(生物学)
核糖核酸
基因
遗传学
免疫学
认识论
哲学
作者
Jillian N. Whelan,Yize Li,Robert H. Silverman,Susan R. Weiss
摘要
With the onset of the 2015 ZIKV outbreak, ZIKV pathogenesis has been of extreme global public health interest, and a better understanding of interactions with the host would provide insight into molecular mechanisms driving the severe neurological outcomes of ZIKV disease. Here is the initial report on the relationship between ZIKV and the host oligoadenylate synthetase-RNase L (OAS-RNase L) system, a potent antiviral pathway effective at restricting replication of diverse viruses. Our study elucidated a unique mechanism whereby ZIKV production is impervious to antiviral RNase L activity, through a mechanism of viral RNA protection that is not mimicked during infection with numerous other RNase L-activating viruses, thus identifying a distinct replication strategy potentially important for ZIKV pathogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI