化学
单萜
吲哚试验
一氧化氮
EC50型
官房
消炎药
体外
生物碱
立体化学
传统医学
生物化学
药理学
有机化学
生物
医学
作者
Yan-Ping Liu,Qinglong Liu,Xianglin Zhang,Hai-Yuan Niu,Chun-Yan Guan,Fu-Kang Sun,Wei Xu,Yan-Hui Fu
标识
DOI:10.1016/j.bioorg.2018.10.013
摘要
Two new monoterpene indole alkaloids, naucleaoffines A (1) and B (2), together with six known alkaloids (3-8), were isolated from the stems and leaves of Nauclea officinalis. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. All isolated compounds were evaluated for their anti-inflammatory activities and anti-HIV-1 activities. Compounds 1-8 exhibited significant inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with IC50 values comparable to that of hydrocortisone. In addition, compounds 1-8 showed significant anti-HIV-1 activities with EC50 ranged from 0.06 to 2.08 µM. These findings suggest that the discoveries of these indole alkaloids with significant anti-inflammatory activities and anti-HIV-1 activities isolated from N. officinalis could be of great importance to the development of new anti-inflammatory and anti-HIV agents.
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