溴甲酚紫
伤口感染
溴甲酚绿
生物医学工程
pH指示剂
渗出液
材料科学
计算机科学
纳米技术
化学
生化工程
工艺工程
外科
医学
色谱法
病理
有机化学
工程类
作者
Clemens Gamerith,Daniel Luschnig,Andreas Ortner,Nikolas Pietrzik,Jan Guse,Michael Burnet,Marieke Haalboom,Job van der Palen,Andrea Heinzle,Eva Sigl,Georg Gübitz
标识
DOI:10.1016/j.snb.2019.126966
摘要
The monitoring of infection status of wounds is an emerging field and the pH of wound exudate is considered one potential indicator of infection. pH indicators intended for use in medical devices, such as swabs or dressings, need to be fixed in place, however, visual pH indicators are usually soluble molecules so are not inherently suitable for use in devices. To address this, we developed a rapid and simple immobilisation method for coupling pH-responsive dyes onto solid phases. The use of a silane based coupling agent for immobilisation of bromocresol purple led to a shift in the pH dependent spectral properties of the resulting material. The pH responsive material changes from yellow to green to blue with rising pH providing an ideal contrast to the reddish colour of most wound exudates. This is a key advantage over currently available alternatives when considering the suitability of this material for incorporation into various medical devices. In addition, we analysed clinical study samples to verify the association between wound infection and elevated pH-values. A device with an embedded indicator that changes to a contrast colour could represent a simple and easy-to-use system for detecting wounds at risk of infection.
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