Abstract In the present study, the method of simulation and Statistical Design of Experiment (DoE) combined approach has been applied to investigating the influence of metallic gasket, flange and bolt on sealing performance. In order to analyze the influence of wavy shape, bolt distribution, wavy height, gasket thickness, top flange thickness, top flange material, gasket materials and bottom flange material, the contribution degree of each factor to the bolt axial force and pressure distribution was taken as the evaluation index. Research results show that the corrugated shape and bolt distribution have the greatest influence on the pressure distribution of gasket and the range of the bolt axial force.