Abstract IA006: Somatic mutation in normal tissues

Abstract Somatic mutations underpin cancer development and have been speculated to contribute to ageing and a range of diseases. Over the past decade, the ability to sequence cancer genomes has transformed our understanding of the genetics and evolution of a wide range of cancers. However, owing to technical limitations, much less is known about the earliest steps of cancer and how cells in our tissues accumulate mutations during normal ageing. In this talk, I will summarize our recent work to unravel the extent of somatic mutation and clonal selection in normal tissues. I will also discuss how recent technological developments are opening new frontiers in this nascent field. Citation Format: Iñigo Martincorena. Somatic mutation in normal tissues [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr IA006.