Research and Application of 2-Iodoxybenzoic Acid in Organic Synthesis

High-valent organoiodine reagents have many reaction characteristics similar to transition metals, and high-valent organoiodine-mediated reactions feature mild reaction conditions, good product selectivity, high yield and environmental friendliness.Therefore, they have been widely studied and applied in organic synthesis.The recent research progress of 2-iodoxybenzoic acid in organic synthesis is reviewed, including the oxidation of hydroxyl group, nitrogen-containing compounds and sulfur-containing compounds, the preparation of α,β-unsaturated carbonyl compounds and esters, and the application in asymmetric synthesis.The recent improvement of IBX is also introduced.Keywords 2-