缺氧(环境)
生物
呼吸系统
高氧
肺
解剖
化学
内科学
氧气
医学
有机化学
作者
Bing Sun,Jian Gao,Lijuan Yang,Songqian Huang,Xiaojuan Cao
标识
DOI:10.1016/j.ijbiomac.2022.04.040
摘要
Air-breathing fish are fascinating because of their ability to survive under hypoxia for a long time by using air-breathing organs (ABOs). Fish ABOs are thought to resemble the mammal lung all along. However, the link between the two has not been studied in depth. Here, we reported a markedly improved respiratory capacity in mice under hypoxia by inhibiting lysyl oxidase-like 2 (LOXL2), inspired from the intestinal air-breathing of loach (Misgurnus anguillicaudatus). Moreover, a posterior intestine (an ABO) transcriptome analysis revealed that the deletion of Loxl2b obviously inhibited PI3K-AKT and TGF-β signaling, meanwhile, induced VEGF signaling, which could cause vasodilation and angiogenesis to improve the air-breathing ability of loach. The same phenomenon was found in LOXL2-inhibition mice under hypoxia, which significantly prolonged their living period relative to wild-type (WT) mice. In addition, compared with WT loach, Loxl2b-/- loach presented enhanced anaerobic metabolism, which could also make itself to better survive in hypoxic environment. This should be the magic of air-breathing fish! Supplied from air-breathing fish, this study provides a novel means of improving respiratory capacity in mammal under hypoxia.
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