生物
DNA损伤
基因
细胞周期检查点
癌症
DNA修复
细胞周期
功能(生物学)
细胞生物学
基因组不稳定性
DNA
癌症研究
遗传学
作者
Pavana Lakshmi Vaddavalli,Björn Schumacher
标识
DOI:10.1016/j.tig.2022.02.010
摘要
The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most frequently mutated gene in human cancers. p53 plays a central role in responding to DNA damage and determines the outcome of the DNA damage checkpoint response by regulating cell cycle arrest and apoptosis. As a consequence of this function, dysfunctional p53 results in cells that, despite a damaged genome, continue to proliferate thus fueling malignant transformation. New insights have recently been gained into the complexity of the p53 regulation of the DNA damage response (DDR) and how it impacts a wide variety of cellular processes. In addition to cell-autonomous signaling mechanisms, non-cell-autonomous regulatory inputs influence p53 activity, which in turn can have systemic consequences on the organism. New inroads have also been made toward therapeutic targeting of p53 that for a long time has been anticipated.
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