Tailoring a luminescent metal − organic framework precise inclusion of Pt-Aptamer nanoparticle for noninvasive monitoring Parkinson's disease

Pathologic α-synuclein (α-Syn) has been implicated as a significant causal agent of Parkinson's disease (PD). Thus, α-Syn is an important target for the development of diagnostic tests and therapeutics for PD. In this work, a fluorescence "turn-on" strategy based on a Tb- luminescent metal−organic framework probe ([email protected]) is developed for the noninvasive monitor of α-Syn via oral delivery. To overcome the harsh gut conditions, acid-stable luminescent Tb-MOF capsules are found to excellently protect aptamer on the surface of Pt nanoparticle via precise pore size of luminescent Tb-MOF. When the α-Syn exists on the gut, the α-Syn can be specially recognized with aptamer in Tb-based luminescent MOF probe. Then Pt-Aptamer/α-Syn complex is released into the gut leading to the notable "turn-on" fluorescence signal to the probe. Additionally, the integrity of luminescent Tb-MOF is retained along the gut and is drained in the feces. Detecting fecal fluorescence intensity may provide a solution to PD detection. The noninvasive fluorescence "turn-on" strategy is a great promising detection progress for the early and potential therapeutics diagnosis of PD.