羟基烷酸
聚羟基丁酸酯
生产(经济)
原材料
生化工程
生物材料
生物技术
业务
化学
工程类
纳米技术
生物
材料科学
经济
细菌
遗传学
有机化学
宏观经济学
作者
Tania Palmeiro‐Sánchez,Vincent O’Flaherty,Piet N.L. Lens
标识
DOI:10.1016/j.jbiotec.2022.03.001
摘要
The first observation of a polyhydroxyalkanoate (PHA) aggregate was in 1888 by Beijenrinck. Despite polyhydroxybutyrate (PHB) being the first type of PHA discovered, it was not extracted and characterized until 1925 by Maurice Lemoigne in France, even before the concept of "macromolecules" was known. After more than 30 years, in 1958, Wilkinson and co-workers rediscovered PHB and its metabolic role in the cells as storage compound. PHB started to be appealing to the industry in the 1980s, when a few companies started to commercialize microbially produced PHAs. During the 1990 s, the focus was on reducing production costs to make PHA production economically feasible, for instance by genetically modified microorganisms and even plants. Since then, many advances have been made: diverse wastes as feedstock, different production processes, and tailored design of biopolymers. This paper summarizes the scientific and technological development of PHAs from their discovery in 1888 until their latest applications and current commercial uses. Future perspectives have been devised too based on the current bottlenecks.
科研通智能强力驱动
Strongly Powered by AbleSci AI