化学
脱羧
喹唑啉
催化作用
冷凝
金属
有机化学
组合化学
热力学
物理
作者
Jiangnan Yang,Zong‐Bo Xie,Liang Jin,Xuehua Chen,Le Zhang
摘要
Quinazoline compounds demonstrate a variety of physiological and pharmacological activities. However, the most common syntheses require large quantities of oxidants, high temperature, and other extreme conditions. In this study, quinazoline compounds were synthesized from the condensation of α-keto acid and 2-aminobenzylamine and then decarboxylation under blue LED irradiation at room temperature without transition metal catalysts or additives. Therefore, we demonstrated that by using α-keto acid as the acyl source, decarboxylation can be realized under blue LED without oxidants, in a simple, mild, and environmentally friendly process.
科研通智能强力驱动
Strongly Powered by AbleSci AI