Antimicrobial and Antioxidant Metabolites From the Cultured Suspension Cells of Marchantia polymorpha L.

Cell suspension culture is an attractive alternative source to wild plant for the production of novel biological metabolites. Hence, in this study, chemical investigation of cell suspension cultivated Marchantia polymorpha L. was performed, and led to the isolation of one new bis-bibenzyl (1), along with nine known analogues (2-10). Those chemical structures were elucidated based on the comprehensive analysis of NMR and MS data. The antioxidant and antibacterial effects of isolated components and crude extracts were evaluated, resulting in the identification of some antioxidant and antibacterial components. Meanwhile, Compare to that of wild grown M. polymorpha, the cell cultivated one was found to produce superior phenol yields, these constituents are of great importance for their antioxidant and antimicrobial activities. The studies conducted so far have established that the cell culture of M. polymorpha can be considered not only as a rich source of phenolic but as promising source of natural antioxidants and antibiotics as well, which is also expected to develop for better usage of this medicinal herb.