驯化
地图集(解剖学)
生物
海马体
核心
进化生物学
动物
神经科学
解剖
生态学
作者
Qi-Jun Zhou,Xingyan Liu,Longlong Zhang,Rong Wang,Tingting Yin,Xiaolu Li,Guimei Li,Yuqi He,Zijing Ding,Ping Ma,Shizhi Wang,Bingyu Mao,Shihua Zhang,Guodong Wang
摘要
Abstract The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves. Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory, such as long-term potentiation and long-term depression. In this study, we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types, cell lineage and molecular features. Using the transcriptomes of 105 057 nuclei from the hippocampus of a Beagle dog, we identified 26 cell clusters and a putative trajectory of oligodendrocyte development. Comparative analysis revealed a significant convergence between dog differentially expressed genes (DEGs) and putative positively selected genes (PSGs). Forty putative PSGs were DEGs in glutamatergic neurons, especially in Cluster 14, which is related to the regulation of nervous system development. In summary, this study provides a blueprint to understand the cellular mechanism of dog domestication.
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