A systematic review and meta-analysis of familial colorectal cancer risk

医学 结直肠癌 家族史 相对风险 内科学 一级亲属 荟萃分析 兄弟姐妹 癌症 人口学 肿瘤科 置信区间 心理学 发展心理学 社会学
作者
Louise Johns,Richard S. Houlston
出处
期刊:The American Journal of Gastroenterology [Lippincott Williams & Wilkins]
卷期号:96 (10): 2992-3003 被引量:694
标识
DOI:10.1111/j.1572-0241.2001.04677.x
摘要

The aim of this study was to identify published studies quantifying familial colorectal cancer (CRC) risks in first-degree relatives of CRC and colorectal adenoma (CRA) cases and, through a meta-analysis, obtain more precise estimates of familial risk according to the nature of the family history and type of neoplasm.Twenty-seven case-control and cohort studies were identified, which reported risks of CRC in relatives of CRC cases and nine, which reported the risk of CRC in relatives of CRA cases. Pooled estimates of risk for various categories of family history were obtained by calculating the weighted average of the log relative risk estimates from studies.The pooled estimates of relative risk were as follows: a first-degree relative with CRC 2.25 (95% CI = 2.00-2.53), colon 2.42 (95% CI = 2.20-2.65), and rectal 1.89 (95% CI = 1.62-2.21) cancer; parent with CRC 2.26 (95% CI = 1.87-2.72); sibling with CRC 2.57 (95% CI = 2.19-3.02); more than one relative with CRC 4.25 (95% CI = 3.01-6.08); relative diagnosed with CRC before age 45, 3.87 (95% CI = 2.40-6.22); and a relative with CRA 1.99 (95% CI = 1.55-2.55).Individuals with a family history of CRC and CRA have a significantly elevated risk of developing CRC compared with those without such a history. Risks are greatest for relatives of patients diagnosed young, those with two or more affected relatives, and relatives of patients with colonic cancers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
田様应助荆轲刺秦王采纳,获得10
刚刚
LUCKY发布了新的文献求助10
1秒前
Komorebi发布了新的文献求助10
1秒前
131发布了新的文献求助50
2秒前
2秒前
听风发布了新的文献求助50
3秒前
3秒前
123456杯可乐完成签到,获得积分20
3秒前
自由山槐发布了新的文献求助100
3秒前
cdercder应助梨涡远点啊采纳,获得10
4秒前
标致咖啡发布了新的文献求助10
5秒前
xinzhuoyang发布了新的文献求助10
5秒前
5秒前
6秒前
知性的剑身完成签到,获得积分10
6秒前
NexusExplorer应助qitan采纳,获得10
6秒前
12发布了新的文献求助20
7秒前
xn201120完成签到 ,获得积分10
7秒前
小鱼干完成签到,获得积分10
8秒前
斯文败类应助海藻采纳,获得10
8秒前
8秒前
9秒前
9秒前
feiqi完成签到 ,获得积分10
10秒前
10秒前
畅快的鸡翅完成签到 ,获得积分10
10秒前
Leo完成签到,获得积分10
10秒前
tian发布了新的文献求助10
10秒前
kelly完成签到,获得积分10
11秒前
安静的从安完成签到,获得积分10
11秒前
自由山槐完成签到,获得积分10
12秒前
12秒前
13秒前
13秒前
xy发布了新的文献求助10
13秒前
Lucas应助xinzhuoyang采纳,获得10
13秒前
所所应助Res_M采纳,获得10
14秒前
科研通AI5应助小鱼干采纳,获得10
14秒前
五岳三鸟完成签到,获得积分10
15秒前
友好凡霜应助耀星采纳,获得10
15秒前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
Understanding Interaction in the Second Language Classroom Context 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3809722
求助须知:如何正确求助?哪些是违规求助? 3354237
关于积分的说明 10369760
捐赠科研通 3070510
什么是DOI,文献DOI怎么找? 1686393
邀请新用户注册赠送积分活动 810922
科研通“疑难数据库(出版商)”最低求助积分说明 766433