纳米载体
固体脂质纳米粒
纳米技术
药物输送
毒品携带者
药代动力学
药理学
药品
化学
载波系统
医学
材料科学
计算机科学
电信
作者
Kamla Pathak,Lav Keshri,Maitri Shah
出处
期刊:Critical Reviews in Therapeutic Drug Carrier Systems
[Begell House Inc.]
日期:2011-01-01
卷期号:28 (4): 357-393
被引量:39
标识
DOI:10.1615/critrevtherdrugcarriersyst.v28.i4.20
摘要
Lipid nanocarriers are on the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery. Owing to their size-dependent properties, lipid nanoparticles offer the possibility for development of new therapeutics and an alternative system to other colloidal counterparts for drug administration. An important point to be considered in the selection of a lipid for the carrier system is its effect on the properties of the nanocarrier and also its intended use, as different types of lipids differ in their nature. Researchers around the globe have tapped the potential of solid lipid nanoparticles (SLNs) in developing formulation(s) that can be administered by various routes such as oral, ocular, parenteral, topical, and pulmonary. Since the start of this millennium, a new generation of lipid nanoparticles, namely nanostructured lipid carriers (NLCs), lipid drug conjugates (LDCs), and pharmacosomes, has evolved that have the potential to overcome the limitations of SLNs. The current review article presents broad considerations on the influence of various types of lipids on the diverse characteristics of nanocarriers, encompassing their physicochemical, formulation, pharmacokinetic, and cytotoxic aspects.
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