430: Discordance between voriconazole dose and plasma concentrations

There is limited data on the effects of drug levels on therapeutic success in fungal infections. A significant correlation between plasma voriconazole levels(>2) and successful Aspergillosis outcomes was reported.(Smith et al.Antimicob Agents Chemother 2006;(50):1570-2). Pharmacodynamic studies as well as recently proposed CSLI voriconazole breakpoints suggest a need for therapeutic monitoring. Multiple drugs used during HSCT can affect the liver cytochrome P450 system, which plays a significant role in voriconazole metabolism.