胸腺细胞
生物
CCL25型
细胞生物学
CD8型
趋化因子受体
趋化因子
受体
免疫学
免疫系统
生物化学
作者
Young Il Choi,Jonathan S. Duke‐Cohan,Wesam Ahmed,Maris Handley,Fanny Mann,Jonathan A. Epstein,Linda K. Clayton,Ellis L. Reinherz
出处
期刊:Immunity
[Elsevier]
日期:2008-12-01
卷期号:29 (6): 888-898
被引量:117
标识
DOI:10.1016/j.immuni.2008.10.008
摘要
Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was further affected by the engagement of T cell receptor complex. Activation of plexinD1 via the ligand, semaphorin 3E, repressed CCL25 chemokine signaling via its receptor CCR9 in CD69+ thymocytes. In the absence of plexinD1, CD69+ thymocytes remained in the cortex, maturing to form ectopic single positive (SP) thymocyte clusters in Plxnd1-deficient fetal liver cell-transplanted mice. As a consequence, the boundary between DP and SP thymocytes at corticomedullary junctions was disrupted and medullary structures formed under the thymic capsule. These results demonstrate the importance of plexinD1 in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients.
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